Conventional, teacher-centered education has traditionally been employed to address students' educational needs by delivering essential knowledge. However, there has been a growing trend towards more innovative teaching methods, such as project-based and student-centered education. This study aimed to develop and assess a projectbased, student-centered approach to teaching entrepreneurship and creativity. This quasi-experimental study in education involved 450 medical students over a five-year period (2019-2023) who enrolled in a creativity course as an optional non-core component of the medical education curriculum. The course was structured into three segments: fundamentals of creativity and models, database searching, proposal writing, reference management, and the conversion of ideas into entrepreneurial plans and projects. The study continued with project-based learning in the creativity course and collected data through open-ended student feedback via WhatsApp regarding the educational method, its impact on student learning, related indicators, and any disadvantages associated with it. Students' scores were compiled in three stages, with a maximum final score of 20. The mean score for students in this course was 17.34 ± 1.54, indicating the achievement of learning objectives. Additionally, approximately 10 to 15 research projects were produced for every 100 students, resulting in teamauthored scientific articles published in reputable journals. A content analysis of open-ended questions identified four dimensions of the educational intervention's impact: personal development, team learning potential, active research skills, and teaching characteristics. However, challenges included the need for additional time, high expectations, the requirement for a continuous process, and the availability of research resources. Project-based and student-centered teaching, along with a constructivist approach in medical sciences courses, are crucial strategies in education. Teachers in the field of medical sciences can utilize these methods to improve their teaching practices