en عمومى General Systematic Review Article <p></p> <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:107%">Healthcare-associated infections (HAIs) and multidrug-resistant organisms threaten patient safety. This systematic review evaluates photocatalytic reactions as continuous, self-disinfecting technologies in hospitals.</span><br> <span style="line-height:107%">Following PRISMA 2020 guidelines, we searched PubMed, Web of Science, Scopus, and Embase. Forty-seven studies were included to assess semiconductor photocatalysts&#39; antimicrobial efficacy against hospital pathogens.</span><br> <span style="line-height:107%">Nearly half (49%) of the studies utilized visible-light-active catalysts (e.g., doped-TiO2). These systems demonstrated high efficacy against superbugs, achieving up to a 4.2 log reduction in Staphylococcus aureus and 99.99% in Methicillin-resistant Staphylococcus Aureus (MRSA). Furthermore, field interventions in intensive care units showed that photocatalytic air purifiers reduced airborne contamination by one order of magnitude and significantly lowered infection acquisition rates.</span><br> <span style="line-height:107%">Photocatalytic processes represent a promising adjunctive infection control strategy, providing constant microbial inactivation under ordinary hospital lighting. Future standardized testing of functional stability in clinical environments is required.</span></span></span><br> &nbsp;</div> Photocatalytic Processes, Hospital Environmental Disinfection, Healthcare-Associated Infections, Titanium Dioxide, Multidrug-Resistant Organisms. 11 31 http://jrhms.thums.ac.ir/browse.php?a_code=A-10-186-7&slc_lang=en&sid=1 Seyed Abolfazl Hosseini 10031947532846002055 10031947532846002055 No Student Research Committee, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran Bahador Pourdel 10031947532846002056 10031947532846002056 No Student Research Committee, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran Erfan Rajabi 10031947532846002057 10031947532846002057 No Student Research Committee, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran Hossein Farash Khayalo 10031947532846002058 10031947532846002058 Yes Research Center for Environmental Health Technology, Iran University of Medical Sciences, Tehran, Iran