en عمومى General Narrative Review <br> &nbsp; <span style="font-size:14px;"><span style="font-family:Times New Roman;">Metabolic syndrome (MetS) is a major public health challenge today and, beyond its physical consequences, may affect various dimensions of daily functioning and well-being. Despite the growing body of studies in this area, heterogeneity in health-related quality of life (HRQOL) assessment instruments has limited the comparison and interpretation of findings. The aim of this narrative review was to examine the available evidence on HRQOL among adults with MetS, focusing exclusively on studies that used the WHOQOL-BREF questionnaire.<p></p>Studies were identified by searching using keywords related to MetS, health-related quality of life, and WHOQOLBREF questionnaire. Eligible articles were selected based on predefined inclusion criteria. This review focused on studies conducted in adult populations that assessed HRQOL using the WHOQOL-BREF instrument. Relevant findings were pooled for validation without conducting formal quality assessment or meta-analysis.<p></p>The evidence reviewed suggests that MetS is commonly associated with reduced HRQOL, particularly in the physical and mental domains of the WHOQOL-BREF. Several studies have reported lower HRQOL scores among individuals with MetS compared with non-diseased populations, and some evidence suggests more severe impairment among women. Findings regarding social relationships and environmental domains were less consistent across studies. In conclusion, the existing literature suggests that MetS is often associated with reduced health-related quality of life, highlighting the importance of considering patient-reported outcomes alongside clinical indicators in the management of MetS.</span></span><br> &nbsp; Metabolic syndrome, health-related quality of life, WHOQOL-BREF, Narrative Review 32 37 http://jrhms.thums.ac.ir/browse.php?a_code=A-10-182-1&slc_lang=en&sid=1 Fatemeh Rezaei Chegini 10031947532846002059 10031947532846002059 No Student Research Committee, Shiraz University of Medical Science, Shiraz, Iran Mohebat Vali 10031947532846002060 10031947532846002060 No Non-Communicable Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Zahra Maleki 10031947532846002061 10031947532846002061 Yes Health Sciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran