Volume 4, Issue 2 (4-2025)                   JRHMS 2025, 4(2): 32-37 | Back to browse issues page

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Rezaei Chegini F, Vali M, Maleki Z. Metabolic syndrome and quality of Life: A narrative review of physical, psychological, and social dimensions. JRHMS 2025; 4 (2) :32-37
URL: http://jrhms.thums.ac.ir/article-1-150-en.html
1- Student Research Committee, Shiraz University of Medical Science, Shiraz, Iran
2- Non-Communicable Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3- Health Sciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
Abstract:   (178 Views)
Metabolic syndrome (MetS) is a major public health challenge today and, beyond its physical consequences, may affect various dimensions of daily functioning and well-being. Despite the growing body of studies in this area, heterogeneity in health-related quality of life (HRQOL) assessment instruments has limited the comparison and interpretation of findings. The aim of this narrative review was to examine the available evidence on HRQOL among adults with MetS, focusing exclusively on studies that used the WHOQOL-BREF questionnaire.

Studies were identified by searching using keywords related to MetS, health-related quality of life, and WHOQOLBREF questionnaire. Eligible articles were selected based on predefined inclusion criteria. This review focused on studies conducted in adult populations that assessed HRQOL using the WHOQOL-BREF instrument. Relevant findings were pooled for validation without conducting formal quality assessment or meta-analysis.

The evidence reviewed suggests that MetS is commonly associated with reduced HRQOL, particularly in the physical and mental domains of the WHOQOL-BREF. Several studies have reported lower HRQOL scores among individuals with MetS compared with non-diseased populations, and some evidence suggests more severe impairment among women. Findings regarding social relationships and environmental domains were less consistent across studies. In conclusion, the existing literature suggests that MetS is often associated with reduced health-related quality of life, highlighting the importance of considering patient-reported outcomes alongside clinical indicators in the management of MetS.

 
Full-Text [PDF 666 kb]   (72 Downloads)    
Type of Study: Narrative Review | Subject: General
Received: 2026/05/21 | Accepted: 2026/05/21 | Published: 2026/06/21

References
1. Tabatabaei-Malazy O, Saeedi Moghaddam S, Rezaei N, Sheidaei A, Hajipour MJ, Mahmoudi N, et al. A nationwide study of metabolic syndrome prevalence in Iran; a comparative analysis of six definitions. PLoS One. 2021;16(3):e0241926. [DOI:10.1371/journal.pone.0241926]
2. Biadgo B, Melak T, Ambachew S, Baynes HW, Limenih MA, Jaleta KN, et al. The Prevalence of Metabolic Syndrome and Its Components among Type 2 Diabetes Mellitus Patients at a Tertiary Hospital, Northwest Ethiopia. Ethiop J Health Sci. 2018;28(5):645-54. [DOI:10.4314/ejhs.v28i5.16]
3. Rezaei Chegini F, Seif M, Vali M, Ghaem H, Masoumi SJ. Health-related quality of life among healthcare workers: a comparative analysis using regression, conditional tree and forests. BMC Public Health. 2025;25(1):4293. [DOI:10.1186/s12889-025-25562-3]
4. Saklayen MG. The Global Epidemic of the Metabolic Syndrome. Curr Hypertens Rep. 2018;20(2):12. [DOI:10.1007/s11906-018-0812-z]
5. Amirkalali B, Fakhrzadeh H, Sharifi F, Kelishadi R, Zamani F, Asayesh H, et al. Prevalence of Metabolic Syndrome and Its Components in the Iranian Adult Population: A Systematic Review and Meta-Analysis. Iran Red Crescent Med J. 2015;17(12):e24723. [DOI:10.5812/ircmj.24723]
6. Saboya PP, Bodanese LC, Zimmermann PR, Gustavo AD, Assumpção CM, Londero F. Metabolic syndrome and quality of life: a systematic review. Rev Lat Am Enfermagem. 2016;24:e2848. [DOI:10.1590/1518-8345.1573.2848]
7. Chen SH, Chen SC, Lai YP, Chen PH, Yeh KY. Abdominal obesity and hypertension are correlated with health-related quality of life in Taiwanese adults with metabolic syndrome. BMJ Open Diabetes Res Care. 2020;8(1). [DOI:10.1136/bmjdrc-2019-000947]
8. Revicki DA. Health-related quality of life in the evaluation of medical therapy for chronic illness. J Fam Pract. 1989;29(4):377-80.
9. Hatami H, Deihim T, Amiri P, Cheraghi L, Azizi F. Association between Metabolic Syndrome and Health-related Quality of Life among Individuals with Normal and Impaired Glucose Regulation: Findings from Tehran Lipid and Glucose Study. Arch Iran Med. 2016;19(8):577-83.
10. Roohafza H, Sadeghi M, Naghnaeian M, Shokouh P, Ahmadi A, Sarrafzadegan N. Relationship between Metabolic Syndrome and Its Components with Psychological Distress. Int J Endocrinol. 2014;2014:203463. [DOI:10.1155/2014/203463]
11. Amiri P, Hosseinpanah F, Rambod M, Montazeri A, Azizi F. Metabolic syndrome predicts poor health-related quality of life in women but not in men: Tehran Lipid and Glucose Study. J Womens Health (Larchmt). 2010;19(6):1201-7. [DOI:10.1089/jwh.2009.1710]
12. Lidfeldt J, Nyberg P, Nerbrand C, Samsioe G, Scherstén B, Agardh CD. Socio-demographic and psychosocial factors are associated with features of the metabolic syndrome. The Women's Health in the Lund Area (WHILA) study. Diabetes Obes Metab. 2003;5(2):106-12. [DOI:10.1046/j.1463-1326.2003.00250.x]
13. Vetter ML, Wadden TA, Lavenberg J, Moore RH, Volger S, Perez JL, et al. Relation of health-related quality of life to metabolic syndrome, obesity, depression and comorbid illnesses. Int J Obes (Lond). 2011;35(8):1087-94. [DOI:10.1038/ijo.2010.230]
14. Tsai AG, Wadden TA, Sarwer DB, Berkowitz RI, Womble LG, Hesson LA, et al. Metabolic syndrome and health-related quality of life in obese individuals seeking weight reduction. Obesity (Silver Spring). 2008;16(1):59-63. [DOI:10.1038/oby.2007.8]
15. Coons SJ, Rao S, Keininger DL, Hays RD. A comparative review of generic quality-of-life instruments. Pharmacoeconomics. 2000;17(1):13-35. [DOI:10.2165/00019053-200017010-00002]
16. Hsiung PC, Fang CT, Chang YY, Chen MY, Wang JD. Comparison of WHOQOL-bREF and SF-36 in patients with HIV infection. Qual Life Res. 2005;14(1):141-50. [DOI:10.1007/s11136-004-6252-z]
17. Liem A, Chih HJ, Velaithan V, Norman R, Reidpath D, Su TT. A comparison of health-related quality of life using the World Health Organization Quality of Life-BREF and 5-Level EuroQol-5 Dimensions in the Malaysian population. Osong Public Health Res Perspect. 2025;16(2):126-40. [DOI:10.24171/j.phrp.2024.0076]
18. Rezaei Chegini F, Seif M, Vali M, Masoumi SJ, Ghaem H. Metabolic syndrome and health-related quality of life: unraveling the role of gender (A SUMS employees cohort-based study). BMC Res Notes. 2025;18(1):466. [DOI:10.1186/s13104-025-07532-5]
19. Pathak V, Dwivedi M, Gutch M. Abstract 154: Correlation of quality of life and metabolic syndrome using WHO QOL BREF version. Indian J Endocrinol Metab. 2022;26(Suppl 1):S54. [DOI:10.4103/2230-8210.342279]
20. Malhotra N, Kulhara P, Chakrabarti S, Grover S. Lifestyle related factors & impact of metabolic syndrome on quality of life, level of functioning & self-esteem in patients with bipolar disorder & schizophrenia. Indian J Med Res. 2016;143(4):434-42. [DOI:10.4103/0971-5916.184284]
21. Jones GL, Sutton A. Quality of life in obese postmenopausal women. Menopause Int. 2008;14(1):26-32. [DOI:10.1258/MI.2007.007034]
22. de Alcantara Sousa LV dSME, Quaresma FRP, de Abreu ACG, da Silva Paiva L, Fonseca FLA, et al. Quality of life and metabolic syndrome in brazilian quilombola communities: a crosssectional study. Journal of Human Growth and Development. 2018;28(3). [DOI:10.7322/jhgd.152182]
23. Yadav R, Yadav RK, Pandey RM, Upadhyay AD. Predictors of Health-Related Quality of Life in Indians with Metabolic Syndrome Undergoing Randomized Controlled Trial of Yoga-Based Lifestyle Intervention vs Dietary Intervention. Behav Med. 2021;47(2):151-60. [DOI:10.1080/08964289.2019.1683711]
24. Cameron AJ, Magliano DJ, Dunstan DW, Zimmet PZ, Hesketh K, Peeters A, et al. A bi-directional relationship between obesity and health-related quality of life: evidence from the longitudinal AusDiab study. Int J Obes (Lond). 2012;36(2):295-303. [DOI:10.1038/ijo.2011.103]
25. Tziallas D, Kastanioti C, Kostapanos MS, Skapinakis P, Elisaf MS, Mavreas V. The impact of the metabolic syndrome on health-related quality of life: a cross-sectional study in Greece. Eur J Cardiovasc Nurs. 2012;11(3):297-303. [DOI:10.1016/j.ejcnurse.2011.02.004]
26. Farzane Rahimpour. Relation between Metabolic Syndrome and Quality of Life in
27. Mashhad Railway Employees. J Mazandaran Univ Med Sci. 2022;211:111-7.
28. Carvalho-Lima RP, Sá-Caputo DC, Moreira-Marconi E, Dionello C, Paineiras-Domingos LL, Sousa-Gonçalves CR, et al. QUALITY OF LIFE OF PATIENTS WITH METABOLIC SYNDROME IS IMPROVED AFTER WHOLE BODY VIBRATION EXERCISES. Afr J Tradit Complement Altern Med. 2017;14(4 Suppl):59-65. [DOI:10.21010/ajtcam.v14i4S.8]
29. Huang B, DePaolo J, Judy RL, Shakt G, Witschey WR, Levin MG, et al. Relationships between body fat distribution and metabolic syndrome traits and outcomes: A mendelian randomization study. PLoS One. 2023;18(10):e0293017. [DOI:10.1371/journal.pone.0293017]
30. Sarrafzadegan N, Gharipour M, Ramezani MA, Rabiei K, Zolfaghar B, Tavassoli AA, et al. Metabolic syndrome and health-related quality of life in Iranian population. J Res Med Sci. 2011;16(3):254-61.

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