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Mashhad University of Medical Sciences
Abstract:   (369 Views)
Background: Nigella sativa (NS) has been suggested in folk medicine to have useful effects during lactation time.
Objectives: This study was done to investigate the effects feeding by the hydro-alcoholic extract of NS during lactation on prolactin level of mothers and weight gain of offspring in propylthiouracil (PTU) induced- hypothyroid and euthyroid rats.
Methods: Forty pregnant rats were randomly divided into 8 groups and treated by: (1) Normal drinking water as a control group; (2) 0.005% PTU in drinking water; (3-5) 100, 200 or 400 mg/ kg hydro-alcoholic extract of NS plus PTU (6-8) 100, 200 or 400 mg/ kg of the plant extract in drinking water without PTU. Mothers received the experimental treatments from the first day after delivery through the lactation period. The offspring continued to receive the experimental treatments up to the first two months of their life.  Ten male offspring of each group were randomly selected and weighted at days 10, 30 and 60 after delivery. Blood samples were collected from mothers after lactation period to determine serum thyroid stimulating hormone(TSH), thyroxin and prolactin levels. On the day 60- post-delivery, the blood samples were collected from offspring to measure serum thyroxin level.
Results: PTU decreased serum thyroxin concentration of mothers and their dams compared to the control ones (P<0.001) which improved by the plant extract (P<0.001). There was no significant difference between the groups in TSH concentration. There was no significant difference between PTU and control groups in duration of lactation period an also in serum prolactin level. All doses of the plant extract increased duration of lactation period of both hypothyroid and euthyroid rats compared to both control and PTU group which was accompanied with serum prolactin concentration (P<0.001). The extract also increased the body weight gain of offspring rats(P < 0.01- P<0.001).
Conclusions: In present study we showed hypothyroid status induced by PTU during lactation period did not change serum prolactin level. Administration of NS extract during lactation period improved prolactin concentrations in both hypothyroid and euthyroid rats, prolonged lactation period and improved weight gain of the offspring.
Type of Study: Research | Subject: General
Received: 2021/03/17 | Accepted: 2021/05/24

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