Volume 1, Issue 3 (9-2022)                   2022, 1(3): 19-29 | Back to browse issues page

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Ghasemi H, Hassani S, Heidarianpour A, Ilbeigi D, Ghasemi H, Ghahremani R, et al . Protective effect of zinc sulfate and continuous/interval training on heart oxidative stress in morphine-withdrawal syndrome in rats. Journal title 2022; 1 (3) :19-29
URL: http://jrhms.thums.ac.ir/article-1-44-en.html
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical sciences, Kashan, Iran , kheiripour-n@kaums.ac.ir
Abstract:   (2812 Views)
Opium abuse results in oxidative damage in several tissues such as heart. We investigated the effect of continuous and interval training (CT and IT) with zinc sulfate (ZS) consumption on oxidative stress in the heart in morphine-dependent rats following withdrawal syndrome (WS).
Seventy male Wistar rats were randomly divided into seven groups: Control, WS rats, WS rats receiving ZS 9 mg/kg by gavage, WS rats with CT, WS rats under IT, WS rats with CT and ZS and WS rats with IT and ZS. Animals were addicted to morphine sulfate. Interval and continuous exercises performed five days/weeks by running on a treadmill. Heart tissue and serum samples were collected and markers of oxidative stress were measured by spectrophotometric methods, also creatine kinase (CK-MB) and troponin I (TPI) were measured by spectrophotometric methods.
The results showed that the receiving ZS along with CT/IT caused increased heart catalase activity and decreased the serum malondialdehyde level as compared to the withdrawal group. In addition, IT/ZS showed significantly increased in superoxide dismutase activity in serum and heart tissue as compared to the morphine withdrawing. Furthermore, it is observed that ZS and CT/IT made a significant reduction in CK-MB and TPI levels in comparison to the morphine group. Also, the IT/ZS supplement reduced the serum level of cholesterol, triglycerides, low-density lipoprotein-cholesterol, Very-low-density lipoprotein-cholesterol and Atherogenic Index compared to the withdrawing group.
In conclusion, CT/IT scheduled exercises therapy combined with ZS improves the oxidative stress in morphine-induced heart injury in WS rats.
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Type of Study: Research | Subject: Special
Received: 2023/10/24 | Accepted: 2024/02/16 | Published: 2024/06/16

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