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Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical sciences, Kashan, Iran , nejatkh.bio@gmail.com
Abstract:   (175 Views)
Opium abuse results in oxidative damage in several tissues such as heart. We investigated the effect of continuous and interval training (CT and IT) with zinc sulfate (ZS) consumption on oxidative stress in the heart on morphine-dependent rats following withdrawal syndrome (WS).
Seventy male Wistar rats were randomly divided into seven groups: Control, WS rats, WS rats receiving ZS 9 mg/kg by gavage, WS rats with CT, WS rats under IT, WS rats with CT and ZS, WS rats with IT and ZS. Animals were addicted by morphine sulfate. Interval and continuous exercises performed five days/weeks by running on a treadmill. heart tissue and serum samples were collected and markers of oxidative stress were measured by spectrophotometric methods, also creatine kinase (CK-MB) and troponin I (TPI)  was measured by spectrophotometric methods.
The results showed that the Receiving ZS along with CT/IT caused increased heart CAT activity and decreased the serum MDA level as compared to the withdrawing group. In addition, IT/ZS showed significantly increased in Superoxide dismutase (SOD) activity in serum and heart tissue as compared to the morphine withdrawing. Additionally, it is observed that ZS and CT/IT made a significant reduction in CK-MB and TPI levels in comparison to the morphine group.  Also, the IT/ZS supplement reduced the serum level of Cho,TG, LDL-C, VLDL-C and Atherogenic Index (AI) compared to the withdrawing group. CT/IT schaduled exercises combined therapy with ZS improves the oxidative stress in morphine-induced heart injury in WS rats.
 
     
Type of Study: Research | Subject: Special
Received: 2022/08/24 | Accepted: 2022/09/18

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