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Diabetes is one of the most common metabolic disorders and is currently considered one of the most important causes of death in human societies. For many years, natural medicines, especially medicinal plants, served as the basis for treatment, with their raw materials used in the pharmaceutical industry. In the present study, the effect of the hydroalcoholic extract of the fruit of the rattle plant on blood sugar and phosphofructokinase-1 (PFK-1) expression was investigated. In this study, 45 male rats (150-300 g) were randomly divided into 3 groups (n= 15) (the healthy group, the diabetic group without treatment, and the diabetic group under the treatment of rattle fruit extract). Type 1 diabetes was induced by the injection of streptozotocin. The diabetic group received 300 mg/kg of rattle fruit extract through gavage for 30 days. The blood glucose level and the expression level of the PFK-1 gene in liver tissue were measured. The results of the present study show that blood glucose was significantly reduced in treated diabetic rats compared to untreated diabetic rats. The extract of the rattle plant fruit does not affect the expression of the phosphofructokinase gene. The present study shows that the consumption of hydroalcoholic extract from the fruit of the rattle plant had an effect on glucose reduction, but it did not affect the level of gene expression.

Keywords: Rat, Diabetes (type 1), Rattle plant, phosphofructokinase-1

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